Mumps is a virus-borne infectious illness. It usually begins with a fever, headache, muscular pains, exhaustion, and a loss of appetite that lasts a few days. The salivary glands of most people will then enlarge (often referred to as parotitis when the parotid gland, located in front and below the ear, swells). The plump cheeks and sensitive, swelling jaw are the result of this.
Signs & Symptoms of Mumps
Mumps is most well-known for causing puffy cheeks and a painful, swollen jaw. This is caused by swelling salivary glands under one or both ears, a condition known as parotitis.
Other signs and symptoms that may appear a few days before the onset of parotitis include:
- Muscle aches
- Loss of appetite
Symptoms typically appear 16-18 days after infection, but this period can range from 12–25 days after infection.
- Mumps can cause moderate symptoms (like a cold) or no symptoms at all, and some individuals are unaware they have the condition.
- Mumps can sometimes lead to more serious issues.
- Mumps usually clear up in two weeks for the majority of people.
Transmission of Mumps
Mumps is a virus-borne infectious illness. It spreads when saliva or respiratory droplets from the lips, nose, or throat come into touch with it. An infected person can spread the virus by
- coughing, sneezing, or talking
- sharing items that may have saliva on them, such as water bottles or cups
- participating in close-contact activities with others, such as playing sports, dancing, or kissing
Mumps can be disseminated from a few days before the salivary glands swell to up to five days after the swelling starts. During this period, somebody with mumps should avoid interacting with others. Stay home from school and avoid social gatherings.
Use of Serology to Aid in the Diagnosis of Mumps Infection
To confirm mumps infection, a buccal swab specimen taken 3 days after the beginning of parotitis is preferable. Detection of mumps immunoglobulin M (IgM) can aid in the diagnosis of mumps although a positive IgM result determines a probable rather than confirmed case, based on the Council of State and Territorial Epidemiologists mumps case definition. A significant rise in immunoglobulin G (IgG) antibody titer in paired acute- and convalescent-phase serum specimens, and IgG seroconversion, can also aid in the diagnosis of mumps infection but are not recommended because they are rarely observed.
The ability to detect IgM in people infected with mumps is influenced by vaccination status and the timing of test collection. IgM detection is highest in unprotected people, middle in one-dose vaccination receivers, and lowest in two-dose vaccine recipients in general. A positive IgM result is more common in samples obtained more than 3 days after the beginning of parotitis.
The sensitivity and specificity of IgM test techniques and kits varies greatly, with certain indirect EIA and immunofluorescent tests identifying as little as 12–15 percent of confirmed mumps infections (Rota et al 2013).
The IgM capture ELISA is the most sensitive serologic approach, identifying 46 percent to 71% of rRT PCR confirmed infections, although it is only available in limited quantities (Rota et al. 2013).
It has been widely known that mumps IgM cannot be detected in previously vaccinated people who get sick with the disease. Regardless of when the material is collected, those who have had mumps immunisation may not have detectable mumps IgM antibodies. Because IgG test results are usually positive and raised at the time of the initial blood collection, detecting a 4-fold spike or seroconversion is improbable and hence not advised.
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Dengue viruses are transmitted to humans via mosquito bites from infected Aedes species (Aedes aegypti or Aedes albopictus). Dengue fever affects over half of the world’s population, or around 4 billion people. Dengue fever is a common cause of illness in high-risk areas.
- 1 in 4: Dengue fever affects about one out of every four persons.
- Symptoms of dengue fever can range from mild to severe.
- Severe dengue fever can be fatal in a matter of hours and generally necessitates hospitalization.
Dengue fever, aches and pains, and a rash are common indications of medical illnesses.
Fever with any of the following symptoms is the most common dengue symptom:
- Vomiting, nausea, and rash
- Any warning symptom (eye discomfort, generally behind the eyes, muscular, joint, or bone pain)
Dengue fever lasts for 2–7 days on average. After a week, the majority of individuals will be back to normal.
- There is no specific treatment for dengue.
Through Mosquito Bites
Aedes aegypti mosquito.
Dengue viruses are transmitted to humans by mosquito bites from infected Aedes species (Ae. aegypti or Ae. albopictus). The Zika and Chikungunya viruses are carried by mosquitos of this species.
- These mosquitoes prefer to bite people and reside both indoors and outdoors near people, laying their eggs near standing water in containers that retain water, such as buckets, bowls, animal dishes, flower pots, and vases.
- Dengue, chikungunya, and Zika mosquitoes bite at all hours of the day and night.
- Mosquitoes become infected by biting a virus-infected human. Infected mosquitoes can then transmit the virus to other humans by biting them.
Aedes albopictus mosquito.
Rarely, dengue can be spread through blood transfusion, organ transplant, or through a needle stick injury.
- See your healthcare provider if you have symptoms of dengue and live in or have recently traveled to an area with risk of dengue.
- A blood test is the only way to confirm the diagnosis.
- Your healthcare provider may order blood tests to look for dengue.
- The Anti-Dengue Virus ELISA (IgM and IgG) is suitable for the serological detection of an acute or a past dengue virus infection.
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Rubella is a virus-borne infectious illness. Rubella causes a mild sickness in most individuals, with symptoms such as a low-grade fever, sore throat, and a rash that begins on the face and spreads to the rest of the body. If a woman is infected with rubella while she is pregnant, it might result in a miscarriage or major birth abnormalities in the kid. MMR (measles-mumps-rubella) vaccination provides the greatest protection against rubella.
Signs and Symptoms
Rubella is typically mild in children, with minimal symptoms. A red rash is usually the first sign in youngsters who do experience symptoms. Other symptoms that may occur 1 to 5 days before the rash appears include:
- a low-grade fever
- mild pink eye (redness or swelling of the white of the eye)
- general discomfort
- swollen and enlarged lymph nodes
- runny nose
Rubella causes a moderate sickness in most people, with a low-grade fever, sore throat, and a rash that begins on the face and spreads to the rest of the body.
Before the rash forms, some individuals may have headaches, pink eye, and overall discomfort.
About 25 to 50 percent of rubella infected persons will not show any symptoms.
Rubella spreads when an infected person coughs or sneezes. Also, if a woman is infected with rubella while she is pregnant, she can pass it to her developing baby and cause serious harm.
A person with rubella may spread the disease to others up to one week before the rash appears, and remain contagious up to 7 days after. However, 25% to 50% of people infected with rubella do not develop a rash or have any symptoms, but they still spread it to others.
This is baby has a mild rash with pink and red spots caused by rubella
Serologic Testing for Rubella and CRS in Low Prevalence Setting
IgM and IgG Detection
Detection of specific IgM antibodies in a serum sample collected within the first few days after rash onset can provide presumptive evidence of a current or recent rubella virus infection. The optimum time-point for collection of serum is five days after the onset of symptoms (fever and rash) when >90% of cases will be IgM positive.
On the day of rash onset only about 50% of cases are IgM positive. Therefore, if serum collected less than five days after onset is negative, a second sample would be necessary to confirm/rule out rubella..
Serological testing for congenital rubella syndrome (CRS)
Congenital Rubella Syndrome (CRS), which can occur when a woman is infected with rubella during a pregnancy, consists of a variety of possible birth defects including cataracts, hearing loss, heart defects, developmental disabilities, and low birthweight. CRS cases can be diagnosed in newborns and young infants using detection of rubella IgM. Suspected cases should be tested as close to birth as possible and again at 1 month of age if the initial IgM test is negative. If paired sera are to be collected, the second sample should be collected 14 to 21 days after the acute specimen was collected. At 3 months of age, approximately 50% of cases would still have detectable rubella IgM in their serum. Additionally, the presence of rubella IgG in an infant after the decline of maternal antibodies (9 months of age) and the absence of vaccination or exposure to rubella will confirm CRS.
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Measles is a contagious respiratory disorder caused by a virus. A disorder of fever (up to 105°F) and malaise, as well as cough, coryza, and conjunctivitis. A person’s rash generally occurs 14 days after being exposed to the virus. The rash spreads from the top of the head down the trunk and down the legs.
Signs and Symptoms
Measles symptoms often develop 7 to 14 days after viral exposure. The rash of measles emerges 3 to 5 days after the initial symptoms.
7 – 14 days after a measles infection: first symptoms show
Measles isn’t just a little rash. Measles can be dangerous, especially for babies and young children. Measles typically begins with
- high fever (may spike to more than 104°),
- runny nose (coryza), and
- red, watery eyes (conjunctivitis).
Complications of Measles
2-3 days after symptoms begin: Koplik spots
Tiny white spots (Koplik spots) may appear inside the mouth two to three days after symptoms begin.
Measles rash appears 3–5 days after symptoms start.
It generally starts as flat red patches around the hairline on the face, then spreads to the neck, torso, arms, legs, and feet.
The spots may become fused together as they travel from the head to the rest of the body, with little raised bumps appearing on top of the flat red patches.
A person’s temperature may go beyond 104° Fahrenheit when the rash emerges.
Transmission of Measles
Measles is a highly infectious virus that grows in the mucus of infected people’s noses and throats. Through coughing and sneezing, it can spread to others.
Other individuals can become sick if they breathe contaminated air or contact an infected surface and then touch their eyes, noses, or mouths.
Measles does not infect or spread among animals.
When you suspect measles, get your first (acute-phase) serum sample as soon as feasible. If the acute-phase serum specimen obtained 3–10 days after rash development is negative and the case has a negative (or not done) result for real-time RT-PCR, a second serum specimen taken 3–10 days after symptom onset is indicated, because the IgM response is not detectable until 3 days after symptom onset in some cases.
Capture IgM Enzyme Linked Immunosorbent Assay (ELISA) and Indirect IgG ELISA
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